Availability and insertion of meta-l and vitamin-derived cofactors are required for the correct structure and function of proteins, thus preventing severe pathological conditions, related to inborn errors of cofactor metabolism.
Methodologies aimed at experimentally predicting or describing the required interactions have allowed dissection of individual step of cofactor assembly, as well as the molecular consequences of alterations of individual steps.
This advanced school will focus on the fundamentals of cofactor biosynthesis, trafficking, and insertion by using either pure recombinant protein or more complex cell/organism models. Basic knowledge of these processes will be translated to pharmacology and pathophysiology.
The advanced school is primarily aimed at young scientists (PhD students, post-docs, junior faculty) active in the fields of biochemistry, chemistry, nutrition, and related disciplines.