The Centre Scientifique de Monaco (C.S.M.) is a monegasc independent public institute founded in 1960 by Prince Rainier III. Even if scientific research has been a tradition in Monaco for more than a century following the Oceanic cruise of Prince Albert Ist, the wishes of Prince Rainier III in creating the C.S.M. was to provide the Principality of Monaco means to conduct its own biological research and support action of governmental organizations and international agencies to protect and conserve marine life. Since 1990, the C.S.M. is mainly studying coastal ecosystems and more particularly tropical and temperate corals in relation to global climate change. His research interests involve techniques ranging from genomics to ecology through biochemistry and physiology.
In 2010, the C.S.M. opened new themes: environmental economics and a funding agency of clinical research in partnership with health care institutions in the Principality. In 2012, in addition to the Marine Biology Department, two new research departments were created: a department of Polar Biology, mainly studying polar birds used as indicators of climate impacts on Subantarctic and Antarctic ecosystems and a department of Medical Biology involving four teams working in cancer biology, biotherapies applied to neuromuscular diseases and gut microbiota. In 2016, the Centre Scientifique de Monaco became a collaborating Center of the World Health Organization.